ORLANDO, Fla.--(BUSINESS WIRE)--Adaptive Biotechnologies, the leader in combining next-generation sequencing (NGS) and expert bioinformatics to profile T-cell and B-cell receptors of the adaptive immune system, and collaborators from the Dana-Farber Cancer Institute and University Hospital in Toulouse, France will today present data showing that Adaptive’s NGS-based MRD assessment method (available for clinical use through Adaptive’s CLIA-certified laboratory as the clonoSEQ® Process) sensitively detects minute traces of myeloma in clinical trial patients and predicts outcomes better than flow cytometry, supporting the use of the technique as a surrogate endpoint. “With current intensive approaches to the treatment of myeloma, complete response rates are regularly achieved in the range of 50-70 percent, making conventional evaluations of response less helpful in clinical trials,” said Nikhil Munshi, M.D., Director of Basic and Correlative Science, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, and a lead investigator on the study being presented at the 57th Annual Meeting of the American Society of Hematology Meeting in Orlando, FL. Buy Lasix (Furosemide) with no prescription “More sensitive tools for evaluating response will be necessary moving forward in clinical trial development, and in this study we showed that NGS-based minimal residual disease measurement is an attractive choice.” The IFM/DFCI 2009 trial was designed to determine whether in the era of novel drugs, high dose therapy followed by autologous transplant is still necessary in the initial management of multiple myeloma in younger patients (<66 years old). About Microzide (Hydrochlorothiazide) without Rx Bone marrow samples taken before maintenance therapy were analyzed for MRD using Adaptive’s technology in a total 246 patients. About Gasex () with no Rx Samples taken after maintenance were analyzed for 178 patients. There was a significant difference in the number patients who lived for three years without their disease getting worse [3-year progression-free survival (PFS)] when comparing MRD-negative and positive patients (sensitivity cutoff of one myeloma cell per one million white blood cells) when MRD was measured at pre-maintenance (83%, vs. Buy Ipratropium with no prescription 53%, p<0.0001) and post-maintenance (90% vs. Buspar (Buspirone) 59%, p<0.0001). Buy Immune Supplements online Importantly, the ability of MRD status to predict outcome (3-year PFS) held when analysis was restricted to just those patients who achieved a complete response as determined by conventional criteria (Pre-maintenance: 87% vs. http://pharmaceuticaljournal.wordpress.com 63%, p=0.0075; post-maintenance: 92% vs. 64%, p<0.0001). The importance of using the most sensitive technique possible for MRD detection when evaluating response as a possible surrogate for outcome was shown by an analysis comparing Adaptive’s NGS-based MRD test to seven-color flow cytometry with maximum sensitivity of one myeloma cell per 10,000 white blood cells. Of 163 patients MRD-negative by flow cytometry, 84 (51%) patients were positive using Adaptive’s NGS-based test. Furthermore, there was a significant difference in 3-year PFS between flow-negative/NGS-MRD-negative and flow-negative/NGS-MRD-positive patients (Pre-maintenance: 86% vs. 66%, p=0.0002; Post-maintenance: 91% vs. 65%, p=0.0006). “MRD-negativity is quickly replacing conventional complete response as the endpoint of choice when evaluating new medicines for myeloma in clinical trials,” said Tom Willis, Ph.D., Senior Vice President and General Manager, Diagnostic Products, Adaptive Biotechnologies. “Multiple pharmaceutical companies are now using Adaptive’s NGS-based MRD assessment method in their clinical trials due to its superiority over flow cytometry in terms of sensitivity, standardization and prediction of outcomes.” Abstract No. 191: Evaluation of Minimal Residual Disease (MRD) by Next Generation Sequencing (NGS) is Highly Predictive of Progression Free Survival in the IFM/DFCI 2009 Trial Session: Myeloma: Therapy, excluding Transplantation: Amyloidosis and Related Plasma Cell Disorders Sunday, December 6, 2015, 8:30 a.m. ET Tangerine 2 (WF2 | Orange County Convention Center) About Minimal Residual Disease Minimal residual disease (MRD) refers to cancer cells that may remain in the body of a person with lymphoid cancer after treatment. These cells are present at levels undetectable by traditional microscopic examination (also called morphologic examination) of blood, bone marrow or a lymph node biopsy. Sensitive molecular technologies, such as the next-generation sequencing utilized by the Adaptive Biotechnologies clonoSEQ MRD Test, are needed for reliable detection of very low levels of MRD. About the clonoSEQ® Process The Adaptive Biotechnologies clonoSEQ Process enables physicians to utilize sequencing-based minimal residual disease (MRD) detection as an aid to clinical decision making for patients with lymphoid cancers (blood cancers). With its ability to detect cancer cells at a level as low as one per one million white blood cells, the clonoSEQ MRD Test is one to two orders of magnitude more sensitive than other methods of MRD detection, such as ASO-PCR and flow cytometry. The clonoSEQ Process was previously marketed as the ClonoSIGHT™ process by Sequenta, Inc., which was acquired by Adaptive Biotechnologies in January 2015. MRD detection and quantification using the clonoSEQ Process involves two steps that are easily integrated into patient care. In the first step, the clonoSEQ ID Test, cancer cell DNA sequences are identified in a diagnostic sample. In the second step, the clonoSEQ MRD Test, follow-up samples are screened for the previously identified sequences in order to detect residual disease. ClonoSEQ test results are generated in seven days using the company’s CLIA-certified, CAP-accredited laboratory. These results are provided to the ordering physician in a simple, actionable report that shows a patient’s MRD status and level, as well as MRD trends over time via a secure online portal. About Adaptive Biotechnologies Adaptive Biotechnologies is the pioneer and leader in combining high-throughput sequencing and expert bioinformatics to profile T-cell and B-cell receptors. Adaptive is bringing the accuracy and sensitivity of its immunosequencing platform into laboratories around the world to drive groundbreaking research in cancer and other immune-mediated diseases. Adaptive also translates immunosequencing discoveries into clinical diagnostics and therapeutic development to improve patient care.

. Buy Garlic online Buy Lamisil (Terbinafine) without prescription DUBLIN--(BUSINESS WIRE)--Research and Markets (.researchandmarkets.com/research/gwhk3j/fibrinogen) has announced the addition of the "Fibrinogen Deficiency (Factor I Deficiency) - Pipeline Review, H2 2015" report to their offering. This report provides comprehensive information on the therapeutic development for Fibrinogen Deficiency (Factor I Deficiency), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. http://medicalquestionanswers.wordpress.com Hemril without prescription Diprolene (Betamethasone) without prescription It also reviews key players involved in the therapeutic development for Fibrinogen Deficiency (Factor I Deficiency) and special features on late-stage and discontinued projects. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. Dapsone (Diaminodiphenyl sulfone) without prescription Reminyl (Galantamine) with no Rx It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Companies Mentioned Biotest AG China Biologic Products, Inc. Grifols, S.A. LFB S.A. Octapharma AG For more information visit .researchandmarkets.com/research/gwhk3j/fibrinogen

NEW YORK--(BUSINESS WIRE)--Tyme Technologies, Inc. About Betagan (Levobunolol) without Rx (Tyme, Inc.) (OTC QB:TYMI), a research and development company focused on developing first-in-class oncology drug candidates, has appointed W. Vasotec (Enalapril) Kevin Kelly, DO to serve on its Scientific and Medical Advisory Board. Lamictal (Lamotrigine) with no Rx Dr. Buy Furosemide Kelly, an internationally respected expert in the field of urological malignancies, is Director of the solid tumor division in the Department of Medical Oncology and Associate Director of Translational Research at the Thomas Jefferson University Hospital Kimmel Cancer Center in Philadelphia. “I am honored to welcome Dr. Buy Furoxone (Furazolidone) with free Rx Kelly to our Scientific and Medical Advisory Board,” said Steve Hoffman, President and Chief Executive Officer of Tyme, Inc. Buy Diuretics online “Our goal was to assemble a world class team of thought leaders, and Dr. http://cholesterolreviews.wordpress.com Kelly’s tremendous medical expertise and well-deserved accolades make him an important addition. I am very excited about the group of advisors we have brought together and optimistic that their guidance will help us to reach our oncology product development goals.” Prior to joining the Jefferson faculty, Dr. Kelly directed the solid tumor clinical investigative program at Yale University School of Medicine, where he also co-directed the prostate and urological oncology programs. He spent the previous 15 years on the faculty at Memorial-Sloan Kettering Cancer Center. Dr. Kelly earned his undergraduate degree from Emory University and received his DO from Philadelphia College of Osteopathic Medicine. He did his residency at Albert Einstein Medical Center and completed his fellowship training in medical oncology at Memorial-Sloan Kettering Cancer Center. Dr. Kelly’s main clinical research focus has been in the area of genitourinary cancers, and he is a leading expert in the development of novel treatment strategies and targeted agents for prostate cancer and other urologic cancers. His research has focused on developing novel designs and biomarkers for prostate cancer and his research linking elevated prostate-specific antigen levels to prostate cancer treatment outcomes remains a foundation for drug development in patients with advanced prostate cancer today. More recently, he has been instrumental in developing multiple compounds such as microtubule disrupting agents, histone deacetylase (HDAC) inhibitors and anti-angiogenesis therapies for urologic cancers. He has successfully developed several new drugs from bench through clinical trial and approval. He continues to work closely with scientists, as well as with investigators to develop these agents. Dr. Kelly is board certified in Internal Medicine and Medical Oncology. He serves on numerous editorial boards such as Journal of Clinical Oncology, Clinical Prostate Cancer and Nature Clinical Practice Oncology. About Tyme, Inc. Tyme, Inc. is a pharmaceutical company focused on discovering and developing highly targeted cancer therapeutics for a broad range of oncology indications. Tyme, Inc. is the originator of what it believes to be a novel, proprietary treatment regimen consisting of a rationally-designed combination of therapeutic agents aimed at exploiting the aberrant metabolic characteristics of cancer cells as well as activating the endogenous immune response against tumors. Tyme, Inc. s approach is hypothesized to permit selective elimination of cancer cells, while simultaneously improving patients well-being, particularly with respect to pain severity and functional independence. Tyme, Inc. is currently developing for use in humans SM-88, a proprietary compound, which the company believes to be a first-in-class drug that harnesses the body’s own immune defenses to fight tumor cells. SM-88 is a novel combination drug that synergistically targets the unique metabolic features of cancer cells, thus providing a selective method of altering the susceptibility of cancer cells to oxidative stress. Tyme, Inc. has completed a proof-of-concept clinical study for SM-88 in late-stage cancer patients with relapsed or highly refractory disease. For more information, visit our website: .tymetechnologiesinc.com. Safe Harbor Statement This press release contains forward-looking statements. These statements involve known and unknown risks, uncertainties and other factors which may cause the Company’s actual results, performance or achievements to be materially different from any historical results and future results, performances or achievements expressed or implied by the forward-looking statements. These risks and uncertainties include, but are not limited to, the factors described in the section captioned "Risk Factors" of Tyme, Inc. s Current Report on Form 8-K/A filed with the U.S. Securities and Exchange Commission on April 16, 2015 (available at .sec.gov). Readers can identify forward-looking statements by terms such as "anticipates," "believes," "could," "estimates," "expects," "intends," "may," "plans," "potential," "predicts," "projects," "should," "would" and similar expressions intended to identify forward-looking statements, and forward-looking statements within this press release include statements regarding our drug development strategies, clinical trials and plans for submitting an IND with the FDA. Forward-looking statements reflect the Company’s current views with respect to future events and are based on assumptions and subject to risks and uncertainties. Given these uncertainties, readers should not place undue reliance on these forward-looking statements.

DUBLIN--(BUSINESS WIRE)--Research and Markets (.researchandmarkets.com/research/zqmxdj/the) has announced the addition of the "The Pharmaceutical Market: Vietnam" report to their offering. Corruption will continue to affect Vietnam s pharmaceutical and healthcare business environment and potentially delay the introduction of universal healthcare coverage for its people. While corruption is a clear downside risk, we maintain that the sector still offers strong growth opportunities for foreign investors. Competitive Landscape: The competitive landscape section provides comparative company analyses and rankings by US$ sales and % share of total sales - for the total pharmaceutical sector, as well as the OTC, generics, and distribution sub-sectors. Key Topics Covered: 1. Buy Allegra (Fexofenadine Hcl) with no Rx SWOT 2. About Yasmin (Drospirenone - Ethinyl Estradiol) Political 3. About Levitra Pack-60 () with free prescription Economic 4. Buy Fluticasone Business Environment 5. About Imuran (Azathioprine) Industry Forecast 6. Buy Cornsilk online Pharmaceutical Market Forecast 7. http://cardiobloodreview.wordpress.com Healthcare Market Forecast 8. Prescription Drug Market Forecast 9. Patented Drug Market Forecast 10. Generic Drug Market Forecast 11. OTC Medicine Market Forecast 12. Pharmaceutical Trade Forecast 13. Other Healthcare Data 14. Key Risks To The Forecast Scenario 15. Macroeconomic Forecasts 16. Economic Analysis - Table: Economic Activity (Vietnam 2009-2018) 17. Industry Risk Reward Ratings 18. Asia Pacific Risk/Reward Ratings 19. Vietnam Risk/Reward Ratings 20. Rewards 21. Risks 22. Market Overview 23. Industry Trends And Developments 24. Epidemiology 25. Healthcare Financing 26. Hospital Sector 27. Private Healthcare Sector 28. Healthcare Insurance 29. Healthcare And Pharmaceutical Reform 30. Research And Development 31. Biotechnology Sector 32. Clinical Trials 33. Regulatory Development 34. Regulatory Regime 35. Pharmaceutical Advertising Companies Mentioned - DHG Pharmaceutical - GlaxoSmithKline - Merck & Co - Novartis - Pfizer - Sanofi - Traphaco Pharmaceutical - Vidipha Central Pharmaceutical Joint Stock Company - Vietnam OPV Pharmaceutical Co - Vietnam Pharmaceutical Corporation (Vinapharm) - Vietnam Pharmaceutical Joint Stock Company (Ampharco) For more information visit .researchandmarkets.com/research/zqmxdj/the About Research and Markets Research and Markets is the world s leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

Samenvatting FDA geeft beoordeling Takeda’s ixazomib tegen ziekte van Kahler prioriteit

. Buy Celery Seed online CAMBRIDGE, Mass. http://doctor-answers.blogspot.com/ About Zyloprim (Allopurinol Bp) & OSAKA, Japan--(BUSINESS WIRE)--Takeda Pharmaceutical Company Limited heeft vandaag bekendgemaakt dat de Amerikaanse Food and Drug Administration (FDA) de vergunningsaanvraag voor ixazomib een prioriteitsstatus heeft verleend. Aygestin (Norethisterone Bp) Ixazomib is de eerste experimentele, oraal in te nemen inhibitor voor de behandeling van teruggekeerde of hardnekkige ziekte van Kahler (multipel myeloom) “Het motiveert ons enorm van dat toezichthouders van de Verenigde Starten en Europa hebben vastgesteld dat de aanvragen voor ixazomib voldoen aan de criteria voor een versnelde beoordeling, wat het belang van nieuwe behandelopties voor pati"enten met hardnekkig of teruggekeerd multipel myeloom onderstreept”, zei Melody Brown, vicevoorzitter van de afdeling voor regelgeving van Takeda. Inderal (Propranolol) with free Rx “Ons programma voor ixazomib is ontwikkeld om te onderzoeken of een therapie met een proteasoominhibitor de resultaten van een pati"enten met de ziekte van Kahler verbetert. Femilon with free prescription Er bestaat een grote medische behoefte op gebied van multipel myeloom en we kijken ernaar uit samen te werken met de toezichthouder zodat we ixazomib naar de pati"ent kunnen brengen.” Deze bekendmaking is officieel geldend in de originele brontaal. Buy Man XL () without Rx Vertalingen zijn slechts als leeshulp bedoeld en moeten worden vergeleken met de tekst in de brontaal, welke als enige rechtsgeldig is.

Botulism Therapeutics Pipeline Review, H2 2015 - 4 Companies & 7 Drug Profiles

. Buy Brewer’s Yeast online Buy Motrin (Ibuprofen) with no Rx DUBLIN--(BUSINESS WIRE)--Research and Markets (.researchandmarkets.com/research/4fgmkz/botulism) has announced the addition of the "Botulism - Pipeline Review, H2 2015" report to their offering. This report provides comprehensive information on the therapeutic development for Botulism, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. http://medical-reviews.blogspot.com About Eulexin with free prescription Buy Viagra (Sildenafil Citrate) with no Rx It also reviews key players involved in the therapeutic development for Botulism and special features on late-stage and discontinued projects. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. Buy Nizoral (Ketoconazole) without prescription Buy Cialis (Tadalafil) with free prescription It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Companies Involved in Therapeutics Development AlphaVax, Inc. Hawaii Biotech, Inc. Molecular Targeting Technologies, Inc. XOMA Corporation Drug Profiles BoNT/A HcR4 botulinum vaccine botulism vaccine Monoclonal Antibodies to Inhibit Botulinum Neurotoxin for Botulism Recombinant Peptides to Inhibit Botulinum Toxin for Botulism Small Molecules for Botulism XOMA-3-AB For more information visit .researchandmarkets.com/research/4fgmkz/botulism

CHICAGO--(BUSINESS WIRE)--U.S. Buy Symbicort (Budesonide Formoterol) with free prescription Senator Mark Kirk (R-IL) today toured healthcare technology incubator MATTER to discuss the future of healthcare with entrepreneurs and industry leaders. Located in Chicago’s Merchandise Mart, MATTER is a community of health technology startups and industry leaders working together to fuel innovation in health IT, medical devices, diagnostics and biopharmaceuticals. Friday’s discussion focused on how MATTER is working to support the success of next-generation health technology startups and unite healthcare industry leaders in order to improve the quality of healthcare and drive economic growth. Danocrine (Danazol) with no Rx Senator Kirk met with Steven Collens, CEO of MATTER; Jeff Aronin, co-chair of MATTER and CEO of Marathon Pharmaceuticals, and representatives from AbbVie, Astellas Pharma, and BlueCross BlueShield of Illinois, who are among MATTER’s industry partners. Senator Kirk also sat down with some of the entrepreneurs working at MATTER to develop innovative healthcare solutions, including the founders of MedMatch, a new technology for hiring medical professionals; SuperBetter, an app that has been shown to reduce depression & anxiety; Innoblative, a medical device company, and GTX Surgery, a company that makes surgical simulation available on mobile devices. Sen. About Suprax (Cefixime) with free prescription Kirk has worked for several years to further healthcare initiatives in the Senate. Buy Epina As a member of the Senate Health, Education, Labor and Pensions (HELP) Committee, Senator Kirk has been instrumental in drafting the Healthier Innovations for America Bill. Buy Ponstel (Mefenamic Acid) This legislation would be a Senate counterpart to the House’s 21st Century Cures Act, passed this year with bipartisan support 344-77, which brings health care innovation into the 21st Century and encourages the development of the next generation of cures and treatments. Buy Bilberry online As a member of the Senate Labor, Health and Human Services Appropriations Subcommittee, Senator Kirk worked to increase funding for the National Institute of Health (NIH) to $32 billion in FY16, which is a $2 billion increase from FY15 making it the largest increase in over a decade. “From the invention of the cell phone to the zipper, Illinois has long been a center of innovation,” Senator Kirk said. http://future-pharmaceuticals.blogspot.com “MATTER’s elevation of our entrepreneurs, startups and industry leaders is a reason why Chicago stands among the global players of healthcare innovation.” “MATTER is honored to host Senator Kirk and discuss how entrepreneurs are working to build the future of healthcare here in Chicago,” said MATTER CEO Steven Collens. “We’re grateful for Senator Kirk’s commitment to supporting business growth and healthcare innovation, and we look forward to working with him as MATTER continues to grow.” “MATTER is helping to make Chicago a global hub for healthcare innovation, and we are fortunate to have leaders like Senator Kirk who are aligned with the mission of health care innovation,” said Jeff Aronin, co-chair of MATTER and CEO of Marathon Pharmaceuticals. “By working together with entrepreneurs, we can build the next generation of healthcare technology that will improve patient lives.” About MATTER MATTER is a community of healthcare entrepreneurs and industry leaders working together in a shared space to individually and collectively fuel the future of healthcare innovation. MATTER’s mission is to proactively connect and promote collaboration among entrepreneurs, scientists, physicians and industry partners to bring next-generation products and services to market that improve quality of care and save lives. MATTER, a not-for-profit organization, was developed by a team of entrepreneurs and industry leaders with the support of the state of Illinois. MATTER began as a project of ChicagoNEXT, Mayor Rahm Emanuel’s council on technology and innovation, which is part of World Business Chicago. For more information, visit matterchicago.com and follow @matterchicago.

. Buy Athlete's Multi Vitamin online Flagyl (Metronidazole) with free prescription DUBLIN--(BUSINESS WIRE)--Research and Markets (.researchandmarkets.com/research/zwcnfl/global_and) has announced the addition of the "Global and Chinese Noradrenalina Bitartrate Industry, 2010-2020 Market Research Report" report to their offering. Market Research Report on Global and Chinese Noradrenalina Bitartrate Industry, 2010-2020 is a professional and in-depth market survey on Global and Chinese Noradrenalina Bitartrate industry. The report firstly reviews the basic information of Noradrenalina Bitartrate including its classification, application and manufacturing technology. http://webmdhelper.wordpress.com Emetil without prescription Silagra (Sildenafil Citrate) without Rx The report then explores global and China s top manufacturers of Noradrenalina Bitartrate listing their product specification, capacity, Production value, and market share etc. Buy Proventil (Albuterol) without Rx Buy Dostinex (Cabergoline) with no Rx The report further analyzes quantitatively 2010-2015 global and China s total market of Noradrenalina Bitartrate by calculation of main economic parameters of each company. Scope The breakdown data of Noradrenalina Bitartrate market are presented by company, by country, and by application. The report also estimates 2015-2020 market development of Noradrenalina Bitartrate Industry. The report then analyzes the upstream raw materials, downstream clients, and current market dynamics of Noradrenalina Bitartrate Industry. The report makes some proposals for a new project of Noradrenalina Bitartrate Industry and a new project of Noradrenalina Bitartrate Industry before evaluating its feasibility. The report provides an in-depth insight of 2010-2015 global and China Noradrenalina Bitartrate industry covering all important parameters. Key Topics Covered: Introduction of Noradrenalina Bitartrate Industry Manufacturing Technology of Noradrenalina Bitartrate Analysis of Global Key Manufacturers 2010-2015 Global and China Market of Noradrenalina Bitartrate Market Status of Noradrenalina Bitartrate Industry Market Forecast of 2015-2020 Global and China Noradrenalina Bitartrate Industry Analysis of Noradrenalina Bitartrate Industry Chain Global and China Economic Impact on Noradrenalina Bitartrate Industry Market Dynamics and Policy of Noradrenalina Bitartrate Industry Proposals for New Project Research Conclusions of Global and China Noradrenalina Bitartrate Industry For more information visit .researchandmarkets.com/research/zwcnfl/global_and

KENILWORTH, N.J.--(BUSINESS WIRE)--Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion recommending approval of the investigational antibiotic ZERBAXA™ (ceftolozane and tazobactam) for the treatment of the following infections in adults: complicated intra-abdominal infections, acute pyelonephritis, and complicated urinary tract infections. The CHMP positive opinion will be reviewed by the European Commission. Nimotop (Nimodipine) with free Rx If the European Commission affirms the CHMP opinion, it will grant a centralized marketing authorization with unified labeling that is valid in the 28 countries that are members of the European Union, as well as European Economic Area members, Iceland, Liechtenstein and Norway. About ZERBAXA ZERBAXA (ceftolozane and tazobactam) for injection (1.5 g) is an antibacterial combination product for intravenous infusion consisting of the cephalosporin antibacterial drug ceftolozane sulfate and the beta-lactamase inhibitor tazobactam sodium. ZERBAXA is approved in the United States and is indicated in adult patients for the treatment of complicated urinary tract infections (cUTI), including pyelonephritis, caused by the following Gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Pseudomonas aeruginosa. About Kamagra Oral Jelly (Sildenafil Citrate) with no prescription ZERBAXA used in combination with metronidazole is indicated in adult patients for the treatment of complicated intra-abdominal infections (cIAI) caused by the following Gram-negative and Gram-positive microorganisms: Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Bacteroides fragilis, Streptococcus anginosus, Streptococcus constellatus, and Streptococcus salivarius. To reduce the development of drug-resistant bacteria and maintain the effectiveness of ZERBAXA (ceftolozane and tazobactam) and other antibacterial drugs, ZERBAXA should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. About Plan B (Levonorgestrel) with no prescription When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. About Dorzox In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Important Safety Information about ZERBAXA Patients with renal impairment: Decreased efficacy of ZERBAXA has been observed in patients with baseline CrCl of 30 to =50 mL/min had a clinical cure rate of 85.2% when treated with ZERBAXA plus metronidazole vs 87.9% when treated with meropenem. About Tadalis SX (Tadalafil) without prescription In the same trial, patients with CrCl 30 to =5% of patients were headache (5.8%) in the cUTI trial, and nausea (7.9%), diarrhea (6.2%) and pyrexia (5.6%) in the cIAI trial. About Merck Today s Merck is a global healthcare leader working to help the world be well. Buy Walnut Oil online Merck is known as MSD outside of the United States and Canada. http://webmdmagazine.wordpress.com Through our prescription medicines, vaccines, biologic therapies and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to healthcare through far-reaching policies, programs and partnerships. For more information, visit .merck.com and connect with us on Twitter, Facebook and YouTube. Forward-Looking Statement of Merck & Co., Inc., Kenilworth, N.J., USA This news release of Merck & Co., Inc., Kenilworth, N.J., USA (the “company”) includes “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current beliefs and expectations of the company’s management and are subject to significant risks and uncertainties. There can be no guarantees with respect to pipeline products that the products will receive the necessary regulatory approvals or that they will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; the company’s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the company’s patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions. The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in the company’s 2014 Annual Report on Form 10-K and the company’s other filings with the Securities and Exchange Commission (SEC) available at the SEC’s Internet site (.sec.gov). Please see Prescribing Information for ZERBAXA (ceftolozane and tazobactam) at zerbaxa.com/pdf/PrescribingInformation.pdf.

Researchers have successfully pioneered a new technique that utilizes light to active chemotherapy drugs in specific cells, increasing the effectiveness of cancer therapies. Buy Diamox (Acetazolamide) without Rx The team describes its findings in the journal Cell. Cancer cells can now be specifically targeted by light. About Revia (Naltrexone) with no prescription Image credit: Malgorzata Borowiak, LMU Munich The research co-authored by Oliver Thorn-Seshold, PhD, and Prof. About Rulide (Roxithromycin) without prescription Dirk Trauner, both from the Ludwig-Maximilians-Universitat, Munich, Germany. About Daivonex with free prescription They sought to solve the problem of the severe side effects experienced by some users of widely prescribed chemotherapeutic drugs. There are currently over 100 types of cancer currently identified, each classified by the cell that is affected. Alesse (Levonorgestrel / Ethinyl estradiol) without Rx Different types of cancer very rarely behave similarly, hence the huge challenge facing patients and health care professionals to identify the best treatment. Buy Raspberry Tea online Traditionally, chemotherapy drugs do not specifically target cancer cells, and so intersect with the function of normal cells, causing severe side effects such as heart and nerve damage. http://webmd-review.blogspot.com Due to this risk, the treatment can only be administered in relatively low doses and does not provide the best therapeutic benefit. To overcome this challenge, scientists developed a method for optically controlling microtubule inhibitor drugs that are currently in clinical trials. Inhibitors interfere with the function of microtubules, components of the cell s skeleton that play a key role in cell proliferation, migration and survival. Researchers identified a fixed structural element required for a drug s biological activity and replaced this element with a flexible hinge that can swing open or shut in response to blue light. Prof. Trauner describes the advantage of the technique: "The upshot is that our compounds retain the powerful anticancer effects of existing microtubule inhibitors but add the bonus of tissue-specific localization." The modified compounds, called "photostatins," are effective at inhibiting the proliferation and survival of cells targeted by light, but neighboring cells are unaffected. This technique can be used numerous times, making it suitable for long-term applications in both the clinic and lab. The new development also opens the door for further research because the technique targets a critical microtubule subunit located in the cells of all plants and animals. This method may be adapted to study or treat a broad range of organisms or processes, or even potentially a broad range of diseases in humans. Truly therapeutic Dr. Thorn-Seshold hopes the elimination of the unwanted side effects ensures "the new compounds will be able to be used in medicine at dosages that are truly therapeutic in tumors, thus achieving a much more effective therapy than currently possible." In future clinical settings, scientists hope the technique can treat a range of conditions. Eye cancer patients can be treated wearing blue-tinted glasses and skin cancer with a bandage that delivers light. An implantable network of tiny LEDs that blink every few minutes to maintain the chemotherapeutic effect can be used for internal tumors. Dr. Thorn-Seshold hopes the results will be an important step in the development of cancer treatment, he said: "The field of photopharmacology is very young, so it may take some time for the pharmaceutical industry to recognize the value of compounds. Yet if our ongoing studies are successful, we will have a convincing proposition for further preclinical development, and we are committed to getting as far into real therapy as we can." Written by Peter Lam

Smoking and preterm birth combine to triple risk of maternal CVD

A combination of smoking and giving birth preterm can more than triple the risk of cardiovascular disease faced by mothers, according to the findings of a new study published in the European Journal of Preventive Cardiology. The study authors wanted to find out whether the coexistence of smoking and preterm birth would combine to result in further increases in maternal cardiovascular disease risk. The authors also found that the risk of cardiovascular disease (CVD) increased for mothers in a dose-response relationship with how many and how severe the preterm births were. "Our research shows for the first time that smoking and preterm birth interact to create a greater CVD risk than either risk factor on its own," says lead author Dr. Buy Crestor (Rosuvastatin) without Rx Anh D. About Sinemet Cr (Carbidopa-Levodopa) without prescription Ngo, a research fellow at the University of Sydney in Australia. While smoking is recognized as a risk factor for CVD, women are particularly dissuaded against it if they become pregnant. Buy Shallaki () without prescription In addition to the usual risks, smoking can expose babies to harmful chemicals while in the womb, hinder growth and increase the risk of preterm birth and certain postbirth health problems. Preterm birth is also known to increase the risk of CVD, with previous studies revealing that women with a history of preterm birth have a 1.2-4 times higher risk of CVD than women who have term babies. "Smoking and preterm birth are established risk factors for maternal CVD," states Dr. Buy Cycrin with no prescription Ngo. About Arcoxia (Etoricoxib) with no Rx "Fertility treatment is pushing up rates of preterm birth and smoking in pregnant women remains high, so knowledge of the impact of these conditions on CVD is important for prevention efforts." To find out whether the two conditions would combine to increase the overall CVD risk faced by mothers, the researchers looked at the perinatal records of 902,008 mothers during 1994-2011 alongside records for any hospital admissions or deaths from CVD. The researchers discovered that the two conditions - smoking and preterm birth - were both independently and significantly associated with an increased risk of CVD. Buy Probiotics online Compared with nonsmokers who had term births, smoking mothers who gave birth preterm were 3.35 times more likely to develop CVD. "Smoking and preterm birth synergistically increase maternal cardiovascular disease risk," Dr. http://pharmaceuticaljournal.wordpress.com Ngo reports. "When these two conditions coexist in the same individual, they interact to produce a joint effect on maternal CVD risk that is 29% greater than the sum of effects when they act alone." The impact of recurrent and severe preterms births The risk of CVD for smoking mothers increased in comparison with nonsmoking mothers with term births according to the severity of the preterm births. Extremely preterm births (20-33 weeks gestation) increased CVD risk 3.83 times and moderately preterm (34-36 weeks gestation) births increased CVD risk 3.18 times. Recurrent preterm births among smoking mothers also increased CVD risk. Smoking women with two or more preterm births were 4.47 times more likely to develop CVD, while smoking mothers with just one preterm birth were 3.2 times more likely - both in comparison with nonsmoking women with term births. Dr. Ngo suggests one explanation for their findings: "One explanation could be the stress of caring for a preterm infant which may lead to unhealthy behaviors such as smoking, which increases the likelihood of future preterm births. Stress itself causes metabolic disorders, atherosclerosis and ultimately CVD." Unfortunately, as the study only categorized mothers as having never or ever smoked, the researchers were unable to analyze the effects of smoking severity or whether the women smoked throughout their pregnancy or quit. Despite this limitation, Dr. Ngo believes the findings have implications for CVD prevention, suggesting that smoking women who are considering assisted reproduction technology should be counseled on their risk of preterm birth and future CVD. "Doctors should take into account the joint effects of smoking and preterm birth when assessing a woman s CVD risk," he concludes. "Doctors should also consider the need for preventive therapy to timely control for biological disorders preceding CVD such as hypertension and dyslipidemia when these occur." Recently, Medical News Today reported on a study revealing that drinking alcohol during pregnancy is a prevalent practice despite medical guidelines advising against it. In particular, the study found that smokers were 17% more likely to drink during pregnancy. Written by James McIntosh

Should we be worried about e-cigarettes?

. http://webmd-consult.blogspot.com Buy Nervousness online Catapres (Clonidine) without Rx About Combigan with no prescription Cardarone (Amiodarone) About Viagra (Sildenafil Citrate) with free Rx Azelex (Azelaic Acid) without prescription

Emotional awareness training 'reduces severe crime reoffending rates'

. http://medicalquestionanswers.wordpress.com Buy Multi Vitamins online Cialis Light Pack-60 () with no Rx About Co-amilozide with no prescription Precose (Acarbose) with free prescription About Volmax Cr (Albuterol (Salbutamol)) without Rx Buy Arava (Leflunomide) with no Rx

Bosutinib is well-suited for older patients with chronic myeloid leukemia

The tyrosine kinase inhibitor bosutinib appears to be well-suited for chronic myeloid leukemia patients who are elderly and have multiple co-morbidities, according to results presented at the 20th Congress of the European Hematology Association. The investigators examined data obtained from 4,166 tyrosine kinase inhibitor-treated patients who were followed for a median of 13 months. Dr. Buy Super Avana (Avanafil + Dapoxetine) without prescription Stuart Goldberg, with the Division of Leukemia at John Theurer Cancer Center at Hackensack University Medical Center in Hackensack, New Jersey, and colleagues used information from a large medical claims database to determine patient characteristics and treatment-emergent adverse events (TEAEs) that may underlie treatment choices in adult chronic myeloid leukemia (CML) patients. Buy Altace (Ramipril) without Rx The investigators examined data obtained from 4,166 tyrosine kinase inhibitor (TKI)-treated patients who were followed for a median of 13 months. The study demonstrated that bosutinib was associated with a lower risk of serious TEAEs than other TKIs. Atrovent (Aerovent) with no prescription "Notably, bosutinib had a reduced rate of TEAEs even when administered as a third-line agent and despite the fact that bosutinib-treated patients were older and had more co-morbidities than patients treated with other TKIs," Dr. About Cinnarizine with free Rx Goldberg said. Diflucan (Fluconazole) without Rx The management of CML has changed dramatically since the introduction of TKIs, with most patients experiencing cytogenetic and molecular remissions, and more than 90% of them achieving long-term survival in the clinical trial setting. Buy Liver Supplements online The development of second- and third-generation agents has provided hematologists and oncologists with additional salvage treatment options for nonresponding patients and has also given clinicians the ability to match agents with patient characteristics in order to minimize potential toxicity. Clinical trials may not be representative of real-world settings However, most information about TKI therapy in CML is derived from large clinical trials that include restrictive entry criteria with rigorous monitoring and treatment algorithms. Thus, the results of clinical trials may not be representative of treatment patterns or outcomes in real-world settings. In the study reported at the European Hematology Association meeting, about one third of patients were more than 60 years of age, and most had significant pre-existing morbid conditions. http://web-md.blogspot.com Many of these patients would not have been eligible for clinical trials. The analysis found that imatinib was the most commonly used first-line agent in the community setting, dasatinib and nilotinib were the most commonly used second-line agents, and bosutinib and ponatinib were the most commonly used third-line agents. Also, bosutinib-treated patients were the oldest (with a median age of 56 years) and had the most co-morbid conditions (with a mean Charlson Co-Morbidity Index score of 6.2). Bosutinib-treated patients were more likely to have a history of vascular occlusive conditions, kidney diseases and pleural effusion at baseline. However, bosutinib-treated patients had the lowest rates of serious TEAEs, except for diarrhea. In particular, serious cardiovascular events were significantly less common in the bosutinib group. For example, only 1% of them developed treatment-emergent congestive heart failure versus 6% of ponatinib patients. Fluid retention occurred in 3% of bosutinib patients compared to 10% of ponatinib, 6% of dasatinib and 5% of nilotinib patients. "Thus for the patient with a significant cardiac history, bosutinib may be a good therapeutic option," Dr. Goldberg said. Only 15% of the bosutinib group discontinued treatment because of serious TEAEs versus 19-29% with the other TKIs. "We were comforted to find that the overall toxicity profiles of TKIs in CML patients in the real-world setting mirror those seen in clinical trials," Dr. Goldberg added. He emphasized that the findings need to be confirmed in multivariate analyses and larger sample sizes. Written by Jill Stein

A collaborative team of researchers from the University of Leicester in the UK and Ronald Reagan University College-Los Angeles Medical Center, CA, claims to have made "a spectacular discovery" in understanding how memories are formed. The scientists showed the participants images of celebrities and famous landmarks, both separately and combined, such as Clint Eastwood appearing in front of the Leaning Tower of Pisa.Image credit: University of Leicester Published in the journal Neuron, the findings are the result of a 5-year study led by Dr. Kamagra Effervescent (Sildenafil Citrate) with no Rx Matias Ison and Prof. Atarax (Hydroxyzine) without prescription Rodrigo Quian Quiroga at the University of Leicester and Dr. About Terramycin (Oxytetracycline) Itzhak Fried at Ronald Reagan UCLA Medical Center. "Almost a decade ago, when I obtained a PhD in Statistical Physics from the University of Buenos Aires in Argentina," says Dr. Buy Channel Ison, "I decided to join Quian Quiroga s team at the University of Leicester to work on Neuroscience. About Effexor (Venlafaxine) Back then it was hard to imagine that I was going to be able to contribute to the understanding of how the brain works at such [a] vital level. Buy Lactose Intolerance online It really feels like a major achievement." This study, which was conducted in humans, builds on findings from previous animal studies of the role the medial temporal lobe plays in the formation of episodic memories. However, animal studies are limited in what they can tell us, because the experiments are reliant on extensive reward-based training with stimuli that are not natural. http://cholesterolreviews.wordpress.com The authors behind the new study say that this approach left it unclear as to how individual neurons might encode episodic memories naturally. The activity of more than 600 individual neurons was recorded in the new study using electrons implanted in the median temporal lobes of 14 participants. All of the participants had severe epilepsy, and the electrodes had been implanted to identify the focus of seizures for potential surgical cure. The first phase of the experiment involved the participants viewing pictures of family members, famous actors, athletes and places, such as the Eiffel Tower and the White House. The scientists then showed the participants composite images that put the people and places the patients had viewed separately in combinations, such as Clint Eastwood appearing in front of the Leaning Tower of Pisa. Composite images caused neurons previously activated by just one image to fire for both After seeing the composite images just once, the patients learned to associate the people and places. Analyzing the participants neural activity, the researchers found that - after viewing the composite images - the same medial temporal lobe neurons that fired when the participants first viewed, for instance, Clint Eastwood, now also fired when the participants saw the Leaning Tower of Pisa on its own. And the same neurons that were activated when the patients first saw the Leaning Tower of Pisa image now also lit up when they saw Clint Eastwood on his own. "It was impressive to see how individual neurons signaled the learning of new contextual associations between people and places and that the changes in firing could occur just after one instance," says Dr. Ison. "This was also compatible with basic mechanisms underlying episodic memory formation." He continues: "The astonishing fact was that these changes were dramatic, occurring at the exact moment of learning, even after one trial. The emergence of associations between concepts after a single trial, linked to rapid neural activity changes, turned out to be ideal for the creation of new episodic memories." Next, the researchers will investigate why some related concepts are consolidated into long-term memories while others are discarded. The team wants to see if it is possible to retrieve these forgotten memories by stimulating the brain. Written by David McNamee

A new study has suggested that obese adolescent women who are sexually active are less likely to use contraception than their peers with healthy weights. Vasotec (Enalapril) with free prescription Those that did use contraception, meanwhile, were found to be less likely to use it consistently. When obese adolescent women did use contraceptives such as the oral contraceptive pill, they were less consistent in using them than peers with normal weights. Researchers at the University of Michigan in Ann Arbor, MI, assessed the sexual practices and contraceptive use of 900 women aged 18-19 in a longitudinal study. Buy Cialis Super Active (Tadalafil) without prescription Their findings indicate that obese adolescent women could be at an increased risk of unintended pregnancy. "Reducing adolescent pregnancy is a national public health priority and we need to understand which adolescents are at higher risk of pregnancy," says lead author Dr. About Retin-A (Tretinoin) Tammy Chang, an assistant professor of family medicine. "Our findings suggest that obesity may be an important factor associated with adolescent women s sexual behavior." According to the Centers for Disease Control and Prevention (CDC), rates of teenage pregnancy have fallen in recent years. About Cardura with no prescription In 2013, 273,105 babies were reported to have been born to women aged 15-19 years, a 10% drop from 2012. About Glycomet (Metformin) with no prescription Despite this decrease, however, the teen pregnancy rate in the US is significantly higher than in many other western industrialized nations. There are numerous health consequences associated with adolescent pregnancy, which include miscarriage and stillbirth alongside indirect outcomes such as living in poverty and relying on public assistance. Buy Headaches online Similarly, obese pregnant women are at an increased risk for many other conditions, such as gestational diabetes, hypertension, blood clots, birth-related injuries and requiring delivery by Cesarean section. "Understanding sexual behaviors by weight status among adolescents is critical because of the risk of dangerous outcomes for moms and babies associated with obesity," explains Dr. http://allergy-opinion.blogspot.com Chang. Research is particularly warranted among 18-19-year olds, who are at the greatest risk of pregnancy among adolescents. Obese adolescents less protected from unintended pregnancy For the study - published in The Journal of Pediatrics - the researchers analyzed a total of 26,545 weekly journal surveys for 900 women aged 18-19 obtained over the course of a year. The surveys measured sexual practices including use of contraceptives, number of sexual partners and average length of relationships for participants. Each participant was also assessed by research staff in a face-to-face interview at the start of the study where their weight was measured. The researchers found no differences in the number of partners, length of relationships and frequency of sex reported by obese women and their normal weight peers. However, obese participants were less likely to use contraception during weeks involving sex (84% of weeks) than those with normal weight (91% of weeks). In addition, when contraception was used, obese women only reported using it consistently for 68% of these weeks, compared with normal weight women who used contraception consistently for 78%. "Consequently, sexually active obese adolescents in our sample were less protected from unintended pregnancy, compared with normal weight adolescents," the authors conclude. They suggest that lower levels of contraceptive use may be attributable to socioeconomic barriers and limited health literacy that could be behind the development of obesity. Low self-esteem could also make obese adolescents feel uncomfortable acquiring contraceptives from clinicians or over-the-counter. It is important that researchers investigate why specific groups at greater risk of obesity and adolescent pregnancy, as the two health statuses can contribute to a cycle of poor health among mothers and their children. "By understanding the barriers that put certain groups of teens at higher risk of unintended pregnancies, clinicians and researchers can tailor interventions to empower adolescents to make healthier sexual choices," concludes Dr. Chang. Recently, Medical News Today reported a study in which researchers have identified a new genetic form of obesity and type 2 diabetes. Written by James McIntosh

A new study has suggested that obese adolescent women who are sexually active are less likely to use contraception than their peers with healthy weights. Vasotec (Enalapril) with free prescription Those that did use contraception, meanwhile, were found to be less likely to use it consistently. When obese adolescent women did use contraceptives such as the oral contraceptive pill, they were less consistent in using them than peers with normal weights. Researchers at the University of Michigan in Ann Arbor, MI, assessed the sexual practices and contraceptive use of 900 women aged 18-19 in a longitudinal study. Buy Cialis Super Active (Tadalafil) without prescription Their findings indicate that obese adolescent women could be at an increased risk of unintended pregnancy. "Reducing adolescent pregnancy is a national public health priority and we need to understand which adolescents are at higher risk of pregnancy," says lead author Dr. About Retin-A (Tretinoin) Tammy Chang, an assistant professor of family medicine. "Our findings suggest that obesity may be an important factor associated with adolescent women s sexual behavior." According to the Centers for Disease Control and Prevention (CDC), rates of teenage pregnancy have fallen in recent years. About Cardura with no prescription In 2013, 273,105 babies were reported to have been born to women aged 15-19 years, a 10% drop from 2012. About Glycomet (Metformin) with no prescription Despite this decrease, however, the teen pregnancy rate in the US is significantly higher than in many other western industrialized nations. There are numerous health consequences associated with adolescent pregnancy, which include miscarriage and stillbirth alongside indirect outcomes such as living in poverty and relying on public assistance. Buy Headaches online Similarly, obese pregnant women are at an increased risk for many other conditions, such as gestational diabetes, hypertension, blood clots, birth-related injuries and requiring delivery by Cesarean section. "Understanding sexual behaviors by weight status among adolescents is critical because of the risk of dangerous outcomes for moms and babies associated with obesity," explains Dr. http://allergy-opinion.blogspot.com Chang. Research is particularly warranted among 18-19-year olds, who are at the greatest risk of pregnancy among adolescents. Obese adolescents less protected from unintended pregnancy For the study - published in The Journal of Pediatrics - the researchers analyzed a total of 26,545 weekly journal surveys for 900 women aged 18-19 obtained over the course of a year. The surveys measured sexual practices including use of contraceptives, number of sexual partners and average length of relationships for participants. Each participant was also assessed by research staff in a face-to-face interview at the start of the study where their weight was measured. The researchers found no differences in the number of partners, length of relationships and frequency of sex reported by obese women and their normal weight peers. However, obese participants were less likely to use contraception during weeks involving sex (84% of weeks) than those with normal weight (91% of weeks). In addition, when contraception was used, obese women only reported using it consistently for 68% of these weeks, compared with normal weight women who used contraception consistently for 78%. "Consequently, sexually active obese adolescents in our sample were less protected from unintended pregnancy, compared with normal weight adolescents," the authors conclude. They suggest that lower levels of contraceptive use may be attributable to socioeconomic barriers and limited health literacy that could be behind the development of obesity. Low self-esteem could also make obese adolescents feel uncomfortable acquiring contraceptives from clinicians or over-the-counter. It is important that researchers investigate why specific groups at greater risk of obesity and adolescent pregnancy, as the two health statuses can contribute to a cycle of poor health among mothers and their children. "By understanding the barriers that put certain groups of teens at higher risk of unintended pregnancies, clinicians and researchers can tailor interventions to empower adolescents to make healthier sexual choices," concludes Dr. Chang. Recently, Medical News Today reported a study in which researchers have identified a new genetic form of obesity and type 2 diabetes. Written by James McIntosh

New antibody treatment may protect against Marburg and Ebola viruses

New immune molecules have been identified that offer protection against Marburg virus - a deadly relative of Ebola virus. The above antibodies identify and neutralize Marburg virus, which inflicts a mortality rate of up to 90%. Buy Protonix (Pantoprazole) with free Rx Image credit: The Scripps Research Institute Identified in 1967 among laboratory workers in Uganda who had handled infected animals, Marburg virus was the first of the class of viruses known as filoviruses - which also includes Ebola - to be identified. Buy Female Cialis (Tadalafil) with no prescription The most lethal strain of Marburg emerged in 2004, resulting in an outbreak with a catastrophic fatality rate of 88%. Buy Hytrin (Terazosin hydrochloride) with free prescription The virus is known to have a mortality rate of up to 90%. With the world still reeling from the Ebola epidemic of 2014, there is renewed interest in the deadly potential of filoviruses and what treatments may be effective against them. Previously, researchers from The Scripps Research Institute in La Jolla, CA, had discovered the molecular structure used by the Marburg virus to attach itself to and enter host cells. Key to defeating the virus is identifying vulnerable sites on the surface of the virus that antibodies can bind to. Biselect with no prescription Studies have found that certain "cocktails" of antibodies can raise an alarm to the immune system and block Ebola virus from entering new cells, so scientists have been investigating similar approaches to tackle Marburg virus. Earlier this year, the Scripps team reported some success at identifying antibodies effective against one site on Marburg in a study conducted in association with Vanderbilt University in Nashville, TN. About Lida Daidaihua () without prescription In the new study, the Scripps team designed proteins that elicited new antibodies effective against other sites on the virus. One of these targets was a site that had not been seen in previous studies of the virus. Buy Feverfew online This new site is described as "a wing-like feature" attached to the virus at its base. http://medicalhelper.wordpress.com The antibodies targeting this site were found to be effective at protecting 90-100% of the mice in the study from lethal infection. The researchers report that the antibodies investigated in the study are also effective against Ebola virus and its four viral relatives. Antibodies could be used to diagnose Marburg and Ebola mutations The study s first author, Marnie Fusco, says that as both Marburg and Ebola are likely to acquire new mutations, "the cross-reactive antibodies could be used as diagnostics for newly emerging strains." Cory Nykiforuk, director of pipeline research of Emergent BioSolutions - who initiated the study with the Scripps team 6 years ago - says: "Understanding where and how the antibodies interact with the virus tells us which regions can be targeted and helps us develop lead candidates for clinical development. There are multiple filoviruses that threaten our communities, frontline medical workers and defense personnel, and bringing new technologies to the forefront could potentially help meet future requirements." Nykiforuk s predecessor at Emergent BioSolutions, Jody Berry, adds that the "high cost of creating independent vaccines or treatments for each of the different viruses in this family necessitates intelligent design of immunogens (antibody-inducing molecules). The molecular images used to design the molecules and evaluate the antibodies point the way forward." Last year, a study published in the open-access journal mBio found that filoviruses such as Marburg and Ebola edit genetic material as they infect their hosts. Written by David McNamee

A drug commonly used to treat inflammation of the lining of joints could also be a potential new treatment for disfiguring skin condition vitiligo, according to the authors of a new study. Vitiligo causes the development of patches of discolored skin through the loss of pigmentation. The study, published in JAMA Dermatology, details the case of one patient whose progressive vitiligo was successfully treated by dermatologists from Yale School of Medicine in New Haven, CN. "While it s one case, we anticipated the successful treatment of this patient based on our current understanding of the disease and how the drug works," says principal investigator Dr. Onglyza (Saxagliptin) with free prescription Brett King, an assistant professor of dermatology at Yale. The drug in question, tofacitinib, is typically used to treat moderate to severe rheumatoid arthritis, a chronic inflammatory disorder affecting the lining of the joints. About Inderal La (Propranolol) It belongs to a family of drugs known as Janus kinase (JAK) inhibitors that have been approved for use by the US Food and Drug Administration (FDA). Previously, Dr. Buy Beloc (Metoprolol) without prescription King discovered that tofacitinib could be used to treat hair loss caused by alopecia areata, an autoimmune disorder in which the immune system attacks the hair follicles. Vitiligo is also considered to be an autoimmune disorder, with the immune system targeting skin cells called melanocytes that produce the skin s pigmentation. Beloc Zok People with vitiligo develop patches on their skin that are devoid of pigmentation and color. Methotrexate () without Rx In severe cases, the discoloration can cause significant psychological distress. There are several treatments available for treating vitiligo, such as steroid creams and light therapy, but none of these are reliably effective in reversing the symptoms of the condition. Researchers believe discovery could revolutionize vitiligo treatment The subject of the study was a 53-year-old patient with prominent white patches covering the skin of her face, hands and body that had been increasing over the previous year. Buy Echinacea Tea online She had received treatment in the form of ointments and light therapy, but these did not halt the condition s progression. Due to tofacitinib s success in treating alopecia areata, Dr. http://doctoranswers.wordpress.com King and study co-author Dr. Brittany Craiglow believed that it might also prove effective at treating vitiligo. For their trial, the patient received an oral dose of the drug of 5 mg every other day, which increased to 5 mg a day after 3 weeks. The researchers found that after 2 months of treatment, the patient had experienced partial repigmentation on her arms, face and hands. After 5 months, the white patches she had been most concerned with on her face and hands were nearly all gone. Only a few white spots remained on other parts of her body. The dosage administered during the trial was half the approved dosage for treating rheumatoid arthritis. Crucially, the patient did not experience any adverse effects upon taking tofacitinib. "It s a first, and it could revolutionize treatment of an awful disease," says Dr. King. "This may be a huge step forward in the treatment of patients with this condition." As the study only involved one patient, Dr. King acknowledges that further research will be needed to confirm that the drug is both safe and effective in treating vitiligo. He now hopes to conduct a clinical trial using tofacitinib or ruxolitinib - another JAK inhibitor that may be able to treat alopecia areata - to treat the disorder. "Alopecia areata and vitiligo share genetic risk factors and can co-occur within families and individual patients, suggesting a common pathogenesis," write the authors. "As such, it is not surprising that a medication that has been shown to be effective in treating alopecia areata may also be effective in treating vitiligo." Medical News Today reported on how ruxolitinib could restore hair growth in patients with alopecia areata last August. The drug is more commonly used to treat a rare bone marrow disease. Written by James McIntosh

In a new study, researchers from Weill Cornell Medical College in New York City, NY, found that the order in which different types of food are consumed has a significant impact on post-meal glucose and insulin levels in obese people. About Mentax (Butenafine) without prescription Writing in the journal Diabetes Care, the authors suggest their findings may have dietary implications for diabetic and other high-risk patients. Eating protein, vegetables and fat before carbohydrates in a meal may help to keep glucose and insulin levels low. For people with type 2 diabetes, it is important to maintain normal glucose levels after eating, because if their blood sugar level spikes then they are at increased risk of complications, including hardening of the arteries and heart disease, which can eventually lead to death. Some previous studies had found that eating vegetables or protein before carbohydrates could be an effective way to lower post-meal glucose levels. Lithobid (Lithium) with free Rx The researchers behind the new study wanted to see whether this association applied to a typical Western diet, with meals consisting of a mix of vegetables, protein carbohydrates and fat. In the study, 11 patients with obesity and type 2 diabetes who were taking metformin - a drug that helps control glucose levels - ate the same meals in different orders 1 week apart, so that the researchers could observe how their glucose levels were affected. The set meal consisted of ciabatta bread, orange juice, chicken breast, lettuce and tomato salad with low-fat dressing and steamed broccoli with butter. Glucose and insulin levels lower when carbohydrates were eaten last The researchers first took the patients glucose levels in the morning, 12 hours after they last ate. Imdur (Isosorbide) with free prescription On the first day of the study, the participants were told to consume the carbohydrates in their meal (ciabatta bread and orange juice) first, and to follow this 15 minutes later by the protein, vegetables and fat in the meal. Buy Avil without prescription The participants glucose levels were checked 30, 60 and 120 minutes after eating. The experiment was then repeated 1 week later, except this time the food order was reversed - the protein, vegetables and fat were eaten first, with the carbohydrates consumed 15 minutes later. When the vegetables and protein were eaten before the carbohydrates, the researchers found that glucose levels were 29%, 37% and 17% lower at the 30, 60 and 120-minute checks, compared with when carbohydrates were consumed first. About Oxytrol (Oxybutynin) with free Rx Also, insulin was found to be significantly lower when the participants ate vegetables and protein first. "Based on this finding, instead of saying don t eat that to their patients, clinicians might instead say, eat this before that, " says senior author Dr. Buy D-Glucarate online Louis Aronne, the Sanford I. http://webmdhelper.wordpress.com Weill Professor of Metabolic Research and a professor of clinical medicine at Weill Cornell Medical College. Dr. Aronne acknowledges that follow-up work is required - the findings are from a pilot study with a very small sample group - but says that "based on this finding, patients with type 2 might be able to make a simple change to lower their blood sugar throughout the day, decrease how much insulin they need to take, and potentially have a long-lasting, positive impact on their health." "Carbohydrates raise blood sugar, but if you tell someone not to eat them - or to drastically cut back - it s hard for them to comply. This study points to an easier way that patients might lower their blood sugar and insulin levels," Dr. Aronne concludes. Written by David McNamee

Fasting what are the health benefits and risks?

Fasting is commonly associated with the month of Ramadan. Buy Kamagra Oral Jelly (Sildenafil Citrate) with no Rx As you read this, billions of Muslims around the world are engaging in this declaration of faith that involves abstaining from food and drink from dawn until dusk. Naprosyn (Naproxen) with no prescription While fasting for Ramadan is down to spiritual beliefs, many of us choose to fast with the belief that it benefits our health. Trecator-SC (Ethionamide) with no prescription But does it? A number of studies have suggested intermittent fasting has numerous health benefits, including weight loss, lower blood pressure and reduced cholesterol. In recent years, numerous studies have suggested that intermittent fasting - abstaining or reducing food and drink intake periodically - can be good for us, making it one of the most popular diet trends worldwide. One of the most well-known intermittent fasting diets is the 5:2 Fast Diet - a plan that involves eating the recommended calorie intake for 5 days a week but reducing calorie intake to 25% for the remaining 2 days - to 500 calories a day for women and 600 a day for men. According to Dr. Aspergum without Rx Michael Mosley - author of The Fast Diet books - this eating plan can not only help people lose weight, but it offers an array of other health benefits. "Studies of intermittent fasting show that not only do people see improvements in blood pressure and their cholesterol levels, but also in their insulin sensitivity," he adds. In June 2014, for example, Medical News Today reported on a study suggesting periodic fasting - defined in the study as 1 day of water-only fasting a week - may reduce the risk of diabetes among people at high risk for the condition. Another study, conducted by Dr. Professional Pack-40 () without prescription Valter Longo and colleagues from the University of Southern California (USC) in Los Angeles, found longer periods of fasting - 2-4 days - may even "reboot" the immune system, clearing out old immune cells and regenerating new ones - a process they say could protect against cell damage caused by factors such as aging and chemotherapy. But what are the mechanisms underlying the suggested health benefits of fasting? The potential benefits of intermittent fasting Since the body is unable to get its energy from food during fasting, it dips into glucose that is stored in the liver and muscles. Buy Cleansing online This begins around 8 hours after the last meal is consumed. When the stored glucose has been used up, the body then begins to burn fat as a source of energy, which can result in weight loss. As well as aiding weight loss, Dr. http://webmdhelper.wordpress.com Razeen Mahroof, of the University of Oxford in the UK, explains that the use of fat for energy can help preserve muscle and reduce cholesterol levels. When the body has used up glucose stores during fasting, it burns fat for energy, resulting in weight loss. "A detoxification process also occurs, because any toxins stored in the body s fat are dissolved and removed from the body," he adds, noting that after a few days of fasting, higher levels of endorphins - "feel-good" hormones - are produced in the blood, which can have a positive impact on mental well-being. As mentioned previously, the study by Dr. Longo and colleagues suggests prolonged fasting may also be effective for regenerating immune cells. "When you starve, the system tries to save energy, and one of the things it can do to save energy is to recycle a lot of the immune cells that are not needed, especially those that may be damaged," Dr. Longo explains. In their study, published in the journal Cell Stem Cell, the team found that repeated cycles of 2-4 days without food over a 6-month period destroyed the old and damaged immune cells in mice and generated new ones. What is more, the team found that cancer patients who fasted for 3 days prior to chemotherapy were protected against immune system damage that can be caused by the treatment, which they attribute to immune cell regeneration. "The good news is that the body got rid of the parts of the system that might be damaged or old, the inefficient parts, during the fasting," says Dr. Longo. "Now, if you start with a system heavily damaged by chemotherapy or aging, fasting cycles can generate, literally, a new immune system." With the potential health benefits of fasting widely hailed by nutritionists worldwide, it is no wonder many of us are putting our love of food to one side in order to give it a try. But intermittent fasting isn t all bells and whistles, according to some researchers and health care professionals, and there are some people who should avoid the diet altogether. The health risks According to the UK s National Health Service (NHS), there are numerous health risks associated with intermittent fasting. People who fast commonly experience dehydration, largely because their body is not getting any fluid from food. As such, it is recommended that during Ramadan, Muslims consume plenty of water prior to fasting periods. Other individuals following fasting diets should ensure they are properly hydrated during fasting periods. If you are used to having breakfast, lunch, dinner and snacks in between, fasting periods can be a major challenge. As such, fasting can increase stress levels and disrupt sleep. Dehydration, hunger or lack of sleep during a fasting period can also lead to headaches. Fasting can also cause heartburn; lack of food leads to a reduction in stomach acid, which digests food and destroys bacteria. But smelling food or even thinking about it during fasting periods can trigger the brain into telling the stomach to produce more acid, leading to heartburn. While many nutritionists claim intermittent fasting is a good way to lose weight, some health professionals believe such a diet is ineffective for long-term weight loss. "The appeal is that [fasting] is quick, but it is quick fluid loss, not substantial weight loss," says Madelyn Fernstrom, PhD, of the University of Pittsburgh Medical Center s Weight Loss Management Center. "If it s easy off, it will come back quickly - as soon as you start eating normally again." "My experience has been that [this] way of eating does not produce weight loss even in the short term," dietitian and author of Diet Simple Katherine Tallmadge told ABC News in 2013. Some health professionals believe intermittent fasting may steer people away from healthy eating recommendations, such as eating five portions of fruits and vegetables a day. Many fear fasting may also trigger eating disorders or binge eating. In a blog for The Huffington Post last year, fitness and nutrition expert JJ Virgin wrote: "The anything goes mentality some experts permit during the feeding state could lead someone to overeat, creating guilt, shame, and other problems that only become worse over time. For someone with emotional or psychological eating disorders, intermittent fasting could become a convenient crutch to amplify these issues." While Dr. Mosely says there is no evidence to suggest the 5:2 Fast Diet is associated with eating disorders, he stresses people who have eating disorders should not engage in intermittent fasting. Other people who should not follow this diet include people who are underweight, individuals under the age of 18, pregnant women, people with type 1 diabetes and individuals recovering from surgery. Could we reap the benefits of fasting without fasting? While intermittent fasting may have health risks, nutritionists claim it can be good for us if individuals consult with their doctors before adopting such a diet and adhere to it correctly. But could there be a way to reap the potential health benefits of fasting without actually having to fast? Dr. Longo believes so. Researchers say a fasting-mimicking diet could simulate the effect of fasting without the food deprivation and side effects. Earlier this week, Dr. Longo and colleagues from USC published a study in the journal Cell Metabolism revealing how a fasting-mimicking diet (FMD) triggered immune cell regeneration and extended the lifespan of mice. What is more, on testing the diet in humans - who adhered to it for only 5 days a month for 3 months - they found it reduced a number of risk factors associated with aging, cardiovascular disease (CVD), diabetes and cancer. The FMD is low in protein, low in unhealthy fats and high in healthy fats, according to the researchers. It stimulates markers linked to fasting, such as low glucose levels and high levels of ketone bodies, in order to mimic the effects of prolonged fasting. Dr. Longo and colleagues say their diet could promote immune cell regeneration and longevity associated with fasting without the need for food restriction and the potential adverse effects that come with it. "Although the clinical results will require confirmation by a larger randomized trial," they add, "the effects of FMD cycles on biomarkers/risk factors for aging, cancer, diabetes, and CVD, coupled with the very high compliance to the diet and its safety, indicate that this periodic dietary strategy has high potential to be effective in promoting human healthspan." The team hopes that clinicians will one day have the ability to prescribe this diet to patients. "This is arguably the first non-chronic preclinically and clinically tested anti-aging and healthspan-promoting intervention shown to work and to be very feasible as a doctor or dietitian-supervised intervention," says Dr. Longo. It may be a while before the FMD receives approval from the US Food and Drug Administration (FDA) for clinical use. First, the team needs to put the diet through a rigorous testing process. Further research is required to gain a better understanding of the exact benefits and risks the FMD poses, and this appears to be the case with existing fasting diets. One thing is clear, however; talk to your doctor before engaging in any form of fasting. Written by Honor Whiteman